TN-001

Pharmaceutical compound From Wikipedia, the free encyclopedia

TN-001 is a non-hallucinogenic psychoplastogen which is under development for the treatment of major depressive disorder and post-traumatic stress disorder (PTSD).[1][2][3][4][5] Its route of administration is unspecified.[1] The drug acts as a serotonin receptor modulator, including as a serotonin 5-HT2A receptor partial agonist and serotonin 5-HT2B receptor antagonist, and has been found to produce psychoplastogenic effects without inducing the head-twitch response.[1][2][3][4][5] It is being developed by Transneural Therapeutics, a spinout of CaaMTech.[1][2][4] As of June 2025, TN-001 is in the preclinical research stage of development.[1][2][3] A clinical trial is being planned.[1] The chemical structure of the drug does not yet appear to have been disclosed.[1]

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