TNNI3K

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TNNI3 interacting kinase is a protein that in humans is encoded by the TNNI3K gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesTNNI3K, CARK, CCDD, TNNI3 interacting kinase
Quick facts Available structures, PDB ...
TNNI3K
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTNNI3K, CARK, CCDD, TNNI3 interacting kinase
External IDsOMIM: 613932; MGI: 2443276; HomoloGene: 41084; GeneCards: TNNI3K; OMA:TNNI3K - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015978

NM_001012364
NM_177066

RefSeq (protein)

NP_001106279
NP_001186256
NP_057062

NP_796040

Location (UCSC)Chr 1: 74.24 – 74.54 MbChr 3: 154.49 – 154.76 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology.[5]

Clinical significance

Mutations in TNNI3K are associated to cardiomyopathies.[6]

References

Further reading

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