TOG superfamily
From Wikipedia, the free encyclopedia
The transporter-opsin-G protein-coupled receptor (TOG) superfamily is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments (TMSs). It includes (1) ion-translocating microbial rhodopsins, (2) G protein-coupled receptors (GPCRs), (3) sweet sugar transporters, (4) nicotinamide ribonucleoside uptake permeases (PnuCs; TC# 4.B.1), (5) 4-toluene sulfonate uptake permeases (TSUPs; TC# 2.A.102), (6) Ni2+–Co2+ transporters; (NiCoTs; TC# 2.A.52), (7) organic solute transporters (OSTs; TC# 2.A.82), (8) phosphate:Na+ symporters (PNaS; TC# 2.A.58), and (9) lysosomal cystine transporters (LCTs; TC# 2.A.43).[1][2]
Families
Currently recognized families within the TOG Superfamily (with TC numbers in blue) include:[3]
- 1.A.14 - The Testis-enhanced Gene Transfer (TEGT) Family
- 1.A.26 - The Mg2+ Transporter-E (MgtE) Family
- 1.A.76 - The Magnesium Transporter1 (MagT1) Family
- 2.A.43 - The Lysosomal Cystine Transporter (LCT) Family
- 2.A.52 - The Ni2+-Co2+ Transporter (NiCoT) Family
- 2.A.58 - The Phosphate:Na+ Symporter (PNaS) Family
- 2.A.82 - The Organic Solute Transporter (OST) Family
- 2.A.102 - The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
- 2.A.123 - The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
- 3.E.1 - The Ion-translocating Microbial Rhodopsin (MR) Family
- 4.B.1 - The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family
- 9.A.14 - The G-protein-coupled receptor (GPCR) Family
