TPK1

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.^[5][6]

AliasesTPK1, HPP20, THMD5, thiamin pyrophosphokinase 1

External IDsOMIM: 606370; MGI: 1352500; GeneCards: TPK1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 7 (human)^[1]

Quick facts Identifiers, Aliases ...

TPK1
Identifiers
Aliases	TPK1, HPP20, THMD5, thiamin pyrophosphokinase 1
External IDs	OMIM: 606370; MGI: 1352500; GeneCards: TPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S4Y
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q35 Start 144,451,941 bp[1] End 144,836,395 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.1 Start 43,321,935 bp[2] End 43,643,212 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa monocyte duodenum Achilles tendon blood gonad endothelial cell testicle granulocyte Top expressed in right kidney proximal tubule epithelium of stomach human kidney pyloric antrum ileum duodenum jejunum mucous cell of stomach genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiamine diphosphokinase activity transferase activity thiamine binding nucleotide binding ATP binding kinase activity Cellular component cytosol Biological process thiamine metabolic process thiamine diphosphate biosynthetic process phosphorylation thiamine-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 27010 29807 Ensembl ENSG00000196511 ENSMUSG00000029735 UniProt Q9H3S4 Q9R0M5 RefSeq (mRNA) NM_001042482 NM_022445 NM_001350879 NM_001350880 NM_001350881 NM_001350882 NM_001350883 NM_001350884 NM_001350885 NM_001350886 NM_001350887 NM_001350889 NM_001350893 NM_001350894 NM_001350895 NM_013861 NM_001311111 RefSeq (protein) NP_001035947 NP_071890 NP_001337808 NP_001337809 NP_001337810 NP_001337811 NP_001337812 NP_001337813 NP_001337814 NP_001337815 NP_001337816 NP_001337818 NP_001337822 NP_001337823 NP_001337824 NP_001298040 NP_038889 Location (UCSC) Chr 7: 144.45 – 144.84 Mb Chr 6: 43.32 – 43.64 Mb PubMed search [3] [4]
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This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]