TRAPPC10

Trafficking protein particle complex subunit 10 is a protein that in humans is encoded by the TRAPPC10 gene.^[4][5]

AliasesTRAPPC10, EHOC-1, EHOC1, GT334, TMEM1, TRS130, TRS30, trafficking protein particle complex 10, trafficking protein particle complex subunit 10

External IDsOMIM: 602103; MGI: 1336209; HomoloGene: 37751; GeneCards: TRAPPC10; OMA:TRAPPC10 - orthologs

Chr.Chromosome 21 (human)^[1]

End44,106,552 bp^[1]

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TRAPPC10
Identifiers
Aliases	TRAPPC10, EHOC-1, EHOC1, GT334, TMEM1, TRS130, TRS30, trafficking protein particle complex 10, trafficking protein particle complex subunit 10
External IDs	OMIM: 602103; MGI: 1336209; HomoloGene: 37751; GeneCards: TRAPPC10; OMA:TRAPPC10 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 44,012,309 bp[1] End 44,106,552 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell granulocyte rectum appendix monocyte stromal cell of endometrium epithelium of colon transverse colon sural nerve islet of Langerhans n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium ion transmembrane transporter activity protein binding Cellular component integral component of membrane cytosol Golgi apparatus TRAPPII protein complex Golgi membrane TRAPP complex Biological process early endosome to Golgi transport COPII vesicle coating intra-Golgi vesicle-mediated transport vesicle-mediated transport sodium ion transport sodium ion transmembrane transport protein complex oligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7109 216131 Ensembl ENSG00000160218 ENSMUSG00000000374 UniProt P48553 Q3TLI0 RefSeq (mRNA) NM_001001723 NM_003274 NM_001351709 NM_001081055 RefSeq (protein) NP_003265 NP_001338638 NP_001074524 Location (UCSC) Chr 21: 44.01 – 44.11 Mb n/a PubMed search [2] [3]
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The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi.

Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.^[5]