TRIM69

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. [5]

PDBOrtholog search: PDBe RCSB
AliasesTRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
Quick facts Available structures, PDB ...
TRIM69
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDsOMIM: 616017; MGI: 1918178; HomoloGene: 18827; GeneCards: TRIM69; OMA:TRIM69 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182985
NM_001301144
NM_001301145
NM_001301146
NM_080745

NM_080510
NM_001379369

RefSeq (protein)

NP_001288073
NP_001288074
NP_001288075
NP_542783
NP_892030

NP_536771
NP_001366298

Location (UCSC)Chr 15: 44.73 – 44.77 MbChr 2: 121.99 – 122.01 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

References

Further reading

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