TRMU

TRMU
Identifiers
Aliases	TRMU, MTO2, MTU1, TRMT, TRMT1, TRNT1, LCAL3, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, tRNA mitochondrial 2-thiouridylase
External IDs	OMIM: 610230; MGI: 1919276; GeneCards: TRMU
Enzyme activity
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,357,340 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,781,595 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; right auricle of heart; ; right lobe of thyroid gland; ; body of pancreas; ; ventricular zone; ; left ovary; ; right ovary;
	Top expressed in
	neural layer of retina; ; right kidney; ; interventricular septum; ; proximal tubule; ; otolith organ; ; neural tube; ; lens; ; utricle; ; ventricular zone; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding; transferase activity; tRNA binding; nucleotide binding; sulfurtransferase activity; ATP binding; methyltransferase activity;
Cellular component	mitochondrion; nucleoplasm;
Biological process	tRNA wobble position uridine thiolation; mitochondrial tRNA thio-modification; tRNA processing; methylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55687
	72026
	ENSG00000100416
	ENSMUSG00000022386
	O75648; Q2PPL5
	Q9DAT5
NM_001008569; NM_001008571; NM_001282782; NM_001282783; NM_001282784;
	NM_001282785; NM_018006
	NM_028063
NP_001269711; NP_001269712; NP_001269713; NP_001269714; NP_060476;
	NP_001269711.1
	NP_082339
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.^[5]^[6]

AliasesTRMU, MTO2, MTU1, TRMT, TRMT1, TRNT1, LCAL3, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, tRNA mitochondrial 2-thiouridylase

External IDsOMIM: 610230; MGI: 1919276; GeneCards: TRMU

Chr.Chromosome 22 (human)^[1]

End46,357,340 bp^[1]

Quick facts Identifiers, Aliases ...

Close

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

TRMU

References

Further reading

Related Articles

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"Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations"