TSPAN6

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.^[5][6]

AliasesTSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6

External IDsOMIM: 300191; MGI: 1926264; HomoloGene: 20700; GeneCards: TSPAN6; OMA:TSPAN6 - orthologs

Chr.X chromosome (human)^[1]

End100,639,991 bp^[1]

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TSPAN6
Identifiers
Aliases	TSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6
External IDs	OMIM: 300191; MGI: 1926264; HomoloGene: 20700; GeneCards: TSPAN6; OMA:TSPAN6 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 100,627,108 bp[1] End 100,639,991 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E3 Start 132,791,817 bp[2] End 132,799,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm parotid gland bronchial epithelial cell nasal epithelium epithelium of nasopharynx tibia mucosa of paranasal sinus olfactory zone of nasal mucosa mucosa of colon mucosa of sigmoid colon Top expressed in saccule transitional epithelium of urinary bladder otic placode otic vesicle endocardial cushion atrioventricular valve medial ganglionic eminence molar abdominal wall neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity Cellular component integral component of membrane integral component of plasma membrane extracellular exosome membrane Biological process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of NIK/NF-kappaB signaling cell surface receptor signaling pathway negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7105 56496 Ensembl ENSG00000000003 ENSMUSG00000067377 UniProt O43657 O70401 RefSeq (mRNA) NM_001278740 NM_001278741 NM_001278742 NM_001278743 NM_003270 NM_019656 RefSeq (protein) NP_001265669 NP_001265670 NP_001265671 NP_001265672 NP_003261 n/a Location (UCSC) Chr X: 100.63 – 100.64 Mb Chr X: 132.79 – 132.8 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.^[6]