TUB (gene)

PDBOrtholog search: PDBe RCSB

AliasesTUB, rd5, RDOB, tubby bipartite transcription factor, TUB bipartite transcription factor

External IDsOMIM: 601197; MGI: 2651573; HomoloGene: 31147; GeneCards: TUB; OMA:TUB - orthologs

Chr.Chromosome 11 (human)^[1]

TUB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S31
Identifiers
Aliases	TUB, rd5, RDOB, tubby bipartite transcription factor, TUB bipartite transcription factor
External IDs	OMIM: 601197; MGI: 2651573; HomoloGene: 31147; GeneCards: TUB; OMA:TUB - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 8,019,244 bp[1] End 8,106,243 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.21 cM Start 108,549,545 bp[2] End 108,633,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pars reticulata pars compacta middle temporal gyrus postcentral gyrus entorhinal cortex superior frontal gyrus superior vestibular nucleus pons ventral tegmental area pituitary gland Top expressed in neural layer of retina dorsomedial hypothalamic nucleus arcuate nucleus subiculum ventromedial nucleus anterior amygdaloid area paraventricular nucleus of hypothalamus dentate gyrus of hippocampal formation granule cell habenula lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol binding protein-containing complex binding G protein-coupled receptor binding intraciliary transport particle A binding Cellular component cytoplasm extracellular region cytosol plasma membrane cilium membrane nucleus Biological process phagocytosis, recognition receptor localization to non-motile cilium response to hormone positive regulation of phagocytosis photoreceptor cell maintenance hearing retina development in camera-type eye protein localization to photoreceptor outer segment response to stimulus phagocytosis protein localization to cilium regulation of G protein-coupled receptor signaling pathway intraciliary transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7275 22141 Ensembl ENSG00000166402 ENSMUSG00000031028 UniProt P50607 P50586 RefSeq (mRNA) NM_003320 NM_177972 NM_021885 RefSeq (protein) NP_003311 NP_813977 NP_068685 Location (UCSC) Chr 11: 8.02 – 8.11 Mb Chr 7: 108.55 – 108.63 Mb PubMed search [3] [4]
Wikidata
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Tubby protein homolog is a protein that in humans is encoded by the TUB gene.^[5][6]

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.^[6]