TUG-891

TUG-891 is an experimental drug which acts as a potent and selective agonist for the free fatty acid receptor FFAR4 (GPR120). It has antiinflammatory effects and regulates metabolism, gastric peptide release and glucose homeostasis, and has been researched in animal models of conditions such as obesity, diabetes and atherosclerosis, as well as cancer.^{[1][2][3][4][5][6][7][8][9]} TUG-891 was one of the first selective FFAR4 agonists developed and while it is useful for in vitro research, it has poor stability in vivo, and so numerous compounds have been developed with improved properties using TUG-891 as the parent compound.^{[10][11][12][13][14]}

CAS Number

• 1374516-07-0

PubChem CID

• 57522038

IUPHAR/BPS

• 6490

ChemSpider

• 28514850

Quick facts Identifiers, CAS Number ...

TUG-891

Identifiers
IUPAC name 3-[4-[[5-fluoro-2-(4-methylphenyl)phenyl]methoxy]phenyl]propanoic acid
CAS Number	1374516-07-0
PubChem CID	57522038
IUPHAR/BPS	6490
ChemSpider	28514850
ChEMBL	ChEMBL2058533
Chemical and physical data
Formula	C23H21FO3
Molar mass	364.416 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC=C(C=C1)C2=C(C=C(C=C2)F)COC3=CC=C(C=C3)CCC(=O)O
InChI InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26) Key:LPGBXHWIQNZEJB-UHFFFAOYSA-N

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