TWF1

TWF1
Identifiers
Aliases	TWF1, A6, PTK9, twinfilin actin binding protein 1
External IDs	OMIM: 610932; MGI: 1100520; HomoloGene: 48140; GeneCards: TWF1; OMA:TWF1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	43,806,328 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	94,487,770 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; palpebral conjunctiva; ; seminal vesicula; ; gingival epithelium; ; epithelium of nasopharynx; ; Achilles tendon; ; oral cavity; ; jejunal mucosa; ; islet of Langerhans; ; rectum;
	Top expressed in
	utricle; ; vestibular sensory epithelium; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; Paneth cell; ; vestibular membrane of cochlear duct; ; transitional epithelium of urinary bladder; ; cumulus cell; ; olfactory epithelium; ; ileum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein tyrosine kinase activity; ATP binding; actin monomer binding; phosphatidylinositol-4,5-bisphosphate binding; cadherin binding; actin binding; protein binding; actin filament binding;
Cellular component	intracellular anatomical structure; cytoskeleton; focal adhesion; filopodium; actin cytoskeleton; cell-cell junction; perinuclear region of cytoplasm; myofibril; ruffle membrane; cytoplasm; cytosol; actin filament;
Biological process	regulation of actin phosphorylation; barbed-end actin filament capping; sequestering of actin monomers; negative regulation of actin filament polymerization; positive regulation of cardiac muscle hypertrophy; regulation of lamellipodium assembly; positive regulation of neuron projection development; peptidyl-tyrosine phosphorylation; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	5756
	19230
	ENSG00000151239
	ENSMUSG00000022451
	Q12792
	Q91YR1
	NM_001242397; NM_002822; NM_198974
	NM_008971
	NP_001229326; NP_002813
	NP_032997; NP_001389738; NP_001389739
	Wikidata
View/Edit Human	View/Edit Mouse

Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene.^[5]^[6] This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.^[6]