Talk:High-fructose corn syrup

There is a publication from the EFSA from Feb 28 2022 that found - the effects of free fructose and free glucose (as monosaccharides) on body weight, liver fat, measures of glucose tolerance, blood lipids and blood pressure did not appear to be different. This is based on 49 Randomized Controlled Trials that were included in the analysis. I wanted to add it as a more recent citation to the current statement on lack of evidence for difference between sucrose and fructose under the High-fructose_corn_syrup#Obesity and metabolic syndrome section but was not sure whether this publication qualifies as meta-analysis / research. The current statement in the article reads - The role of fructose in metabolic syndrome has been the subject of controversy, but as of 2022, there is no scientific evidence that fructose or HFCS has any impact on cardiometabolic markers when substituted for sucrose - but the provided citations are a book from 2010 and a meta-analysis originally published in 2020.

Additionally it might be useful to have a simple statement on HFCS being advised against for people with Fructose malabsorption#Unfavorable_foods_(i.e._more_fructose_than_glucose). I am not sure where to put this though. Citation. Ujwal.Xankill3r (talk) 19:38, 5 October 2022 (UTC)

EFSA added. It's certainly not primary. Need some time to figure out where to put tolerance. Artoria2e5 🌉 06:28, 2 February 2023 (UTC)

The whole EFSA report is here (conclusions). It's not clear that the edit made is useful in making the article easier for the common user to understand. The information on China doesn't add anything useful, WP:UNDUE. Zefr (talk) 07:29, 2 February 2023 (UTC)

This revert was justified because 1. the Chinese content and sources are trivial (and inaccessible) for the English encyclopedia, WP:UNDUE; and 2. the content added about fructose vs. sucrose does not clarify the understanding for the common user about HFCS (see discussion under 4.1 Dietary sources in the EFSA report); also see WP:MEDMOS - writing for the wrong audience. The EFSA report was intended to focus on the European use of a different manufacturing ingredient - "isoglucose", not HFCS (American "corn syrup"), as stated in section 4.1, stating: "In the EU, where glucose–fructose syrups are consumed three times less frequently than in the United States (kg/capita), they are not necessarily produced from corn, and are referred to as ‘isoglucose’".

The first two conclusions of the EFSA report were: 1."An upper limit or a safe level of intake for either total, added or free sugars could not be established." 2. "The health effects of added vs. free sugars could not be compared."

The EFSA report is both mostly offtopic for this article and did not have clear conclusions to add to this article. Zefr (talk) 18:28, 2 February 2023 (UTC)

• If the European names are due & included, I do not see why the Chinese stuff is somehow undue. As the sections have established, China is a major supplier of high-fructose syrups to neighboring countries.
• We need something else to do the "as of 2022" then. Any suggestions?
• We do not have an independent "isoglucose" article. Its health effects are to be discussed together, unless we do a (very pointless IMO) split.

Artoria2e5 🌉 09:00, 7 February 2023 (UTC)

Can someone explain to me how industry separates glucose from fructose using liquid chromatography when producing high-fructose corn syrup.

I've seen some sources say it is ion-exchange chromatography, but as you know both glucose and fructose are mostly neutral molecules.

I've seen this quoted: "The chemical properties of glucose and fructose that influence their solubility in ionic liquids include their molecular size and shape, hydrogen bonding capability, and the presence of hydroxyl (-OH) groups. While glucose and fructose have similar molecular weights, their structural differences – such as the presence of a pyranose ring in glucose and a furanose ring in fructose – can affect their interactions with the ionic liquid, leading to different solubilities."

I've seen talk of using simulated moving bed chromatography, but I want to know what the stationary phase and what the separation method is being used.

vossman (talk) 01:45, 20 April 2023 (UTC)

I posted an answer here, if anyone wants to translate to Wikipedia that would be great. I am sick of having my edits deleted, so I stopped 10 years ago.

https://chemistry.stackexchange.com/questions/173012/how-does-industry-separates-glucose-from-fructose-using-liquid-chromatography-wh

vossman (talk) 13:34, 20 April 2023 (UTC)

The Starch EU links lead to a 404 site 77.187.169.166 (talk) 16:40, 22 April 2025 (UTC)

Fixed. Zefr (talk) 18:53, 22 April 2025 (UTC)