Taltirelin

Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects,^[1] and little development of tolerance following prolonged dosing.^[2] It has nootropic,^[3] neuroprotective^[4] and analgesic effects.^[5]

Other names(4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide

AHFS/Drugs.comInternational Drug Names

Routes of
administrationOral

ATC code

• none

Quick facts Clinical data, Other names ...

Taltirelin

Clinical data
Other names	(4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Identifiers
IUPAC name N-{[(4S)-1-methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide
CAS Number	103300-74-9 Y 201677-75-0
PubChem CID	656609
IUPHAR/BPS	2143
ChemSpider	102734 N
UNII	DOZ62MV6A5
ChEBI	CHEBI:135653
CompTox Dashboard (EPA)	DTXSID0043763
Chemical and physical data
Formula	C17H31N7O9
Molar mass	477.475 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N
InChI InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1 N Key:LQZAIAZUDWIVPM-SRVKXCTJSA-N N
NY (what is this?)  (verify)

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Taltirelin is primarily being researched for the treatment of spinocerebellar ataxia; limited research has also been carried out with regard to other neurodegenerative disorders, e.g., spinal muscular atrophy.^[6][7][8]