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Terephthalate 1,2-dioxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Terephthalate 1,2-dioxygenase (EC 1.14.12.15) is an enzyme that catalyzes the chemical reaction
| Terephthalate 1,2-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.15 | ||||||||
| CAS no. | 162032-76-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are terephthalic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylic acid and NAD+.[1][2]
This enzyme is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of this enzyme class is benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating). Other names in common use include benzene-1,4-dicarboxylate 1,2-dioxygenase, and 1,4-dicarboxybenzoate 1,2-dioxygenase. It is a Rieske protein containing an iron–sulfur cluster and participates in the metabolism of terephthalic acid.[1]
