Testis expressed 15
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Testis expressed 15 is a protein that in humans is encoded by the TEX15 gene.[5]
| TEX15 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | TEX15, CT42, testis expressed 15, testis expressed 15, meiosis and synapsis associated, SPGF25 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605795; MGI: 1934816; HomoloGene: 12837; GeneCards: TEX15; OMA:TEX15 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The TEX15 gene displays testis-specific expression, maps to chromosome 8, contains four exons and encodes a 2789-amino acid protein.[6] The TEX15 gene encodes a DNA damage response factor important in meiosis. TEX15 is also a nuclear effector of the mammalian piRNA pathway, required for silencing of transposable elements within the developing germline. [7]
Animal studies
In mice, disruption of an ortholog of the TEX15 gene caused a drastic reduction in testis size and meiotic arrest in males.[8] TEX15, in mice, is required for chromosome synapsis, meiotic recombination and DNA double-strand break repair.[8] Furthermore, TEX15 regulates the loading of recombination proteins (RAD51 and DMC1) onto sites of DNA double-strand breaks, and its absence causes a failure of meiotic recombination.
Clinical significance
A mutation in the TEX15 gene was found to be associated with male infertility and meiotic maturation arrest.[6]
Truncation variants of TEX15 are also potential breast cancer risk factors.[9]
