Dr Drabble, a psychiatrist, blackmails one of his recently cured patients — the naif, Matthew — to kidnap his wife from the Dice House, where she is undergoing therapy. He explains that she has been brainwashed by a second psychiatrist, Dr/ Ratner, into pursuing 'Dice Therapy', a process by which patients are encouraged to make all decisions based on the whim of dice.
The plot is then sidelined to make way for a series of comic skits, based around the amusing activities of the residents of the Dice House: pubic shaving, cross dressing, car theft, murder and one man's battle against the Slow Assassins. Dr Drabble's ill-considered scheme thus plays out as farce in the background, as it becomes transparent he is more insane than his wife.
In a dramatic climax, the fate of both doctors is determined by a single roll of the dice.[3]