Rob Horton – The protagonist of the story. Rob and his father, Robert Horton, moved from Jacksonville to Lister after his mother's (Caroline Horton) death. He stays at the Kentucky Star Motel along with his father who works there. He is a silent kid and usually gets bullied. He also discovers the tiger in the cage.
Sistine Bailey – Sistine (or Sissy) and her mother move to Lister. Sistine is Rob's classmate. Sistine's parents are divorced after her father had an affair with his secretary. As compared to Rob, she is very open emotionally and gets judged by other people at school.
Willie May – Housekeeper of the Kentucky Star. Though uneducated, she gives old people advice to Rob and Sistine, leading Sistine to claim she is a prophetess. She and Rob both have a connection to losing a loved one.
Robert Horton – Rob's dad. He works at the Kentucky Star Motel and is underpaid by Beauchamp.
Caroline Horton – Rob's mom. She died of lung cancer before Rob and his dad moved to Lister, Florida.
Beauchamp – Owner of the Kentucky Star motel, the woods behind the motel, and the tiger.
The Tiger – The tiger is described as a beautiful and poor animal trapped cruelly in a cage where he cannot leave. He paces around in the cage and is fed by Beauchamp and then Rob. After Rob and Sistine let the tiger out of its cage, it was shot by Rob's dad, killing it.
Cricket – Willie May's childhood pet parakeet that she lets go and eventually is thought to be killed by a snake.
Norton and Billy Threemonger – Two "redneck" brothers who bully Rob in school and on the bus.
Mrs. Bailey – Sistine's mom. She babies Sistine and forces her to wear dresses. Her husband cheated on her with his secretary.
Mr. Phelmer – Principal of Rob's school who views Rob as a nuisance, neglects him, and feels uncomfortable talking to him. He later tells Rob that he cannot come to school in case the strange rash on his legs is contagious.
Billy Threemonger - Bully of Robinson Horton who used to bully Sistine Bailey.
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