Thelephoric acid

Thelephoric acid
Names
	Preferred IUPAC name 2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b′]bis([1]benzofuran)-6,12-dione
Identifiers
CAS Number	479-64-1 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:144238;
ChEMBL	ChEMBL3236668;
ChemSpider	30776833;
PubChem CID	135464206;
CompTox Dashboard (EPA)	DTXSID201028792 ;
	InChI InChI=1S/C18H8O8/c19-7-1-5-11(3-9(7)21)25-17-13(5)15(23)18-14(16(17)24)6-2-8(20)10(22)4-12(6)26-18/h1-4,19-22H Key: PDICCECAPKBDBB-UHFFFAOYSA-N; InChI=1/C18H8O8/c19-7-1-5-11(3-9(7)21)25-17-13(5)15(23)18-14(16(17)24)6-2-8(20)10(22)4-12(6)26-18/h1-4,19-22H Key: PDICCECAPKBDBB-UHFFFAOYAC;
	SMILES c1c2c(cc(c1O)O)oc3c2C(=O)c4c(c5cc(c(cc5o4)O)O)C3=O;
Properties
Chemical formula	C18H8O8
Molar mass	352.254 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Thelephoric acid is a terphenylquinone pigment that is found in several fungi, such as Omphalotus subilludens^[1] and Polyozellus multiplex.^[2] Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.^[3]^[4] It is derived from atromentin, and its precursor can be from cyclovariegatin. Fragmentation patterns have suggested that polymers of thelephoric acid exists.

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