ThroLy score
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The Thrombosis Lymphoma (ThroLy) predictive score is a multivariable model for assessing the probability of thromboembolic events in patients with lymphoma. (Multivariable models are those that incorporate multiple independent variables.)
The ThroLy score was developed and published in 2016 by a group of physicians from Serbia and the United States.[1] As a simple model, it was initially internally validated based on individual clinical and laboratory patient characteristics that identify lymphoma patients at risk for a thromboembolic event. Based on an investigation that was conducted on derivation and validation cohorts, it was determined that the variables independently associated with a risk of thromboembolism in lymphoma patients are: previous venous and/or arterial events; mediastinal involvement; a BMI greater than 30 kg/m2; reduced mobility; extra-nodal localization; neutropenia; and a hemoglobin level less than 100g/L.[1][2]
| Patient characteristics | Assigned score |
|---|---|
| Previous venous thromboembolic event | 2 |
| Reduced mobility | 1 |
| Previous acute myocardial infarction or stroke | 2 |
| Obesity (BMI ≥ 30) | 2 |
| Extranodal localization | 1 |
| Mediastinal involvement | 2 |
| Neutropenia | 1 |
| Hemoglobin˂100g/L | 1 |