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Thymidine kinase 1

Human protein and coding gene From Wikipedia, the free encyclopedia

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.[5]

AliasesTK1, TK2, Thymidine kinase 1
External IDsOMIM: 188300; MGI: 98763; GeneCards: TK1
PDBOrtholog search: PDBe RCSB
Quick facts TK1, Identifiers ...
TK1
Identifiers
AliasesTK1, TK2, Thymidine kinase 1
External IDsOMIM: 188300; MGI: 98763; GeneCards: TK1
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.7.1.21↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003258
NM_001346663
NM_001363848

NM_001271729
NM_009387

RefSeq (protein)

NP_001333592
NP_003249
NP_001350777

NP_001258658
NP_033413

Location (UCSC)Chr 17: 78.17 – 78.19 MbChr 11: 117.71 – 117.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
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Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

Interactions

Thymidine kinase 1 has been shown to interact with P21.[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Thymidine Kinase 1 in Cancer

Elevations in serum TK-1 have been found to correlate with the return of breast and other forms of cancer[7] TK-1 can be used to detect cancer earlier, determine what stage it is in, and detect recurrence. Thymidine kinase 1 can be measured based on its enzyme activity[8] or using immunoassay.[9]

References

Further reading

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