Tlapalizquixochtzin
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| Tlapalizquixochtzin | |
|---|---|
| Queen regnant of Ecatepec | |
| Reign | c. early 16th century |
| Empress consort of the Aztec Empire Queen consort of Tenochtitlan | |
| Tenure | c. early 16th century |
| Co-consort | Teotlalco |
| Spouse | Moctezuma II |
| Issue | Francisca de Moctezuma |
| Father | Matlaccoatzin |
Tlapalizquixochtzin was an Aztec noblewoman and Queen regnant of the Aztec city of Ecatepec. She was also a consort of Moctezuma II.[1][2]

She was born as a Princess – daughter of Matlaccoatzin and thus a granddaughter of the King Chimalpilli I and sister of Princess Tlacuilolxochtzin.[2]
Tlapalizquixochtzin married Aztec emperor Moctezuma II (c. 1466 – June 1520). Their daughter was Doña Francisca de Moctezuma.[2]
Her nephew was King Diego de Alvarado Huanitzin.[3]