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Toluene dioxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, toluene dioxygenase (EC 1.14.12.11) is an enzyme that catalyzes the chemical reaction
| toluene dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.11 | ||||||||
| CAS no. | 120038-36-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are toluene, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol and reduced NAD+.[1][2][3]
This enzyme is an oxidoreductase, that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of this enzyme class is toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating). This enzyme is also called toluene 2,3-dioxygenase. It is an iron–sulfur protein that uses flavin adenine dinucleotide as a cofactor and participates in toluene and xylene degradation.[1]
