Transamidation
From Wikipedia, the free encyclopedia
Transamidation is a chemical reaction in which an amide reacts with an amine to generate a new amide:
- RC(O)NR'2 + HNR"2 → RC(O)NR"2 + HNR'2
The reaction is rarely employed, but it could prove relevant to peptide synthesis.[1]
Amides are characteristically inert, but the amino substituents can be exchanged in the presence of Lewis acid and organometallic catalysts.[2] Primary amides (RC(O)NH2) are more amenable to this reaction.