Transcriptional activator LAG-3

Available protein structures:
PDB	IPR021587 PF11498 (ECOD; PDBsum)
AlphaFold	IPR021587; PF11498;

Activator_LAG-3
Activator_LAG-3
	crystal structure of the csl-notch-mastermind ternary complex bound to dna
Identifiers
Symbol	Activator_LAG-3
Pfam	PF11498
InterPro	IPR021587
PDB
Available protein structures:
PDB	IPR021587 PF11498 (ECOD; PDBsum)
AlphaFold	IPR021587; PF11498;

SymbolActivator_LAG-3

In molecular biology, the transcriptional activator LAG-3 is a transcriptional activator protein. The C. elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12.^[1] Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1.^[1]

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