Translin

TSN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J1J, 3PJA, 3QB5, 4WYV
Identifiers
Aliases	TSN, BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, translin
External IDs	OMIM: 600575; MGI: 109263; HomoloGene: 3397; GeneCards: TSN; OMA:TSN - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	121,767,853 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	118,239,469 bp
RNA expression pattern
	Top expressed in
	gonad; ; secondary oocyte; ; skin of hip; ; optic nerve; ; skin of thigh; ; ganglionic eminence; ; thoracic diaphragm; ; germinal epithelium; ; islet of Langerhans; ; superficial temporal artery;
	Top expressed in
	trigeminal ganglion; ; endothelial cell of lymphatic vessel; ; Rostral migratory stream; ; renal corpuscle; ; primitive streak; ; medullary collecting duct; ; vestibular sensory epithelium; ; neural tube; ; Paneth cell; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nuclease activity; endonuclease activity; sequence-specific DNA binding; protein binding; mRNA binding; hydrolase activity; RNA binding; single-stranded DNA binding; identical protein binding; endoribonuclease activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	DNA recombination; nucleic acid phosphodiester bond hydrolysis; RNA metabolic process; RNA phosphodiester bond hydrolysis, endonucleolytic; production of siRNA involved in RNA interference;
	Sources:Amigo / QuickGO
Orthologs
	7247
	22099
	ENSG00000211460
	ENSMUSG00000026374
	Q15631
	Q62348
	NM_001261401; NM_004622
	NM_011650
	NP_001248330; NP_004613
	NP_035780
	Wikidata
View/Edit Human	View/Edit Mouse

Translin is a DNA-binding protein that in humans is encoded by the TSN gene.^[5]^[6]^[7] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).^[8]^[9]^[10]