Trifunctional purine biosynthetic protein adenosine-3

Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene.^[5]

AliasesGART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

External IDsOMIM: 138440; MGI: 95654; GeneCards: GART

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 21 (human)^[1]

Quick facts GART, Identifiers ...

GART
Identifiers
Aliases	GART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
External IDs	OMIM: 138440; MGI: 95654; GeneCards: GART
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MEJ, 1MEN, 1MEO, 1NJS, 1RBM, 1RBQ, 1RBY, 1RBZ, 1RC0, 1RC1, 1ZLX, 1ZLY, 2QK4, 2V9Y, 4EW1, 4EW2, 4EW3, 4ZZ2, 4ZZ3, 4ZZ1, 4ZYV, 4ZZ0, 4ZYY, 4ZYX, 4ZYZ, 4ZYT, 4ZYU, 4ZYW
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.1.2.2 ↗ ↗ ↗ ↗ 6.3.3.1 ↗ ↗ ↗ ↗ 6.3.4.13 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,503,931 bp[1] End 33,543,491 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 53.18 cM Start 91,418,074 bp[2] End 91,443,840 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence rectum smooth muscle tissue epithelium of colon body of pancreas gastric mucosa trabecular bone islet of Langerhans tonsil Top expressed in Ileal epithelium epiblast primitive streak yolk sac embryo somite extraocular muscle ventricular zone embryo morula More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding phosphoribosylglycinamide formyltransferase activity metal ion binding ligase activity catalytic activity hydroxymethyl-, formyl- and related transferase activity ATP binding phosphoribosylformylglycinamidine cyclo-ligase activity phosphoribosylamine-glycine ligase activity Cellular component cytoplasm cytosol extracellular exosome Biological process purine nucleotide biosynthetic process glycine metabolic process 'de novo' IMP biosynthetic process brainstem development biosynthesis response to organic substance cerebellum development ribonucleoside monophosphate biosynthetic process tetrahydrofolate biosynthetic process response to inorganic substance purine ribonucleoside monophosphate biosynthetic process cerebral cortex development metabolism purine nucleobase biosynthetic process adenine biosynthetic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 2618 14450 Ensembl ENSG00000262473 ENSG00000159131 ENSMUSG00000022962 UniProt P22102 Q64737 RefSeq (mRNA) NM_000819 NM_001136005 NM_001136006 NM_175085 NM_010256 NM_001357351 RefSeq (protein) NP_000810 NP_001129477 NP_001129478 NP_780294 NP_034386 NP_001344280 Location (UCSC) Chr 21: 33.5 – 33.54 Mb Chr 16: 91.42 – 91.44 Mb PubMed search [3] [4]
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This protein is a trifunctional polypeptide. It has phosphoribosylamine—glycine ligase (EC 6.3.4.13), phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), AIR synthetase (FGAM cyclase) (EC 6.3.3.1) activity which is required for de novo purine biosynthesis.