Trimecaine
From Wikipedia, the free encyclopedia
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| Names | |
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| IUPAC name
N2,N2-Diethyl-N1-(2,4,6-trimethylphenyl)glycinamide | |
| Systematic IUPAC name
2-(Diethylamino)-N-(2,4,6-trimethylphenyl)acetamide | |
| Other names
N2,N2-diethyl-N-mesitylglycinamide | |
| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
| ECHA InfoCard | 100.009.535 |
| EC Number |
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| KEGG | |
| MeSH | D014288 |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C15H24N2O | |
| Molar mass | 248.36386 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Trimecaine (systematic name (2,4,6-trimethylphenylcarbamoylmethyl)diethylammonium chloride, chemical formula C15H25ClN2O) is an organic compound used as a local anesthetic and cardial antiarrhythmic. It is white crystalline powder readily soluble in water and ethanol.[1] It is an active ingredient in products available under trademarks Mesdicain, Mesocain, Mesokain and others.[2]
Action mechanism, pharmacokinetics
Like other local anesthetics belonging in the amide group trimecaine decreases the cell membrane permeability, causes depolarization and shortens the action potential.[3] Anesthetic effect starts within 15 minutes and remains 60–90 minutes. Its biological half-life is ca. 90 minutes. 10% of trimecaine is excreted unchanged (90% as its metabolites). It passes through the hematoencephalic and placental barriers.[4]
Indication
Trimecaine has two main application fields. The first one is local anesthesia (topical, infiltrational, topical mucosal and inhalational, spinal and Bier's intravenous). It is used in concentrations 0.4 up to 4%, in some cases (e.g. in stomatology) in mixtures with adrenaline. The other field is prophylaxis and therapy of ventriculous arrhythmia on myocardial infarction and in cardiosurgery. It is used also for prophylaxis of sympathetic reaction during tracheal intubations.[3][4]