Tromantadine
Antiviral medicine used to treat herpes simplex virus
From Wikipedia, the free encyclopedia
Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.[1][2]
Trade namesViru-Merz
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| Trade names | Viru-Merz |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Topical (gel) |
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| ECHA InfoCard | 100.053.409 |
| Chemical and physical data | |
| Formula | C16H28N2O2 |
| Molar mass | 280.412 g·mol−1 |
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Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.
Mechanism
Tromantadine inhibits the early and late events in the virus replication cycle.[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.[citation needed]
