Troponin C, skeletal muscle

TNNC2
Identifiers
Aliases	TNNC2, troponin C2, fast skeletal type, CFAP85, FAP85
External IDs	OMIM: 191039; MGI: 98780; HomoloGene: 55727; GeneCards: TNNC2; OMA:TNNC2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,833,745 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,621,887 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; gastrocnemius muscle; ; thoracic diaphragm; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; body of tongue; ; triceps brachii muscle; ; deltoid muscle;
	Top expressed in
	intercostal muscle; ; soleus muscle; ; medial head of gastrocnemius muscle; ; masseter muscle; ; tibialis anterior muscle; ; body of femur; ; thoracic diaphragm; ; skeletal muscle tissue; ; muscle of thigh; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; metal ion binding; calcium-dependent protein binding; actin filament binding; calcium ion binding;
Cellular component	cytosol; troponin complex;
Biological process	regulation of muscle contraction; skeletal muscle contraction; muscle filament sliding;
	Sources:Amigo / QuickGO
Orthologs
	7125
	21925
	ENSG00000101470
	ENSMUSG00000017300
	P02585
	P20801
	NM_003279
	NM_009394
	NP_003270
	NP_033420
	Wikidata
View/Edit Human	View/Edit Mouse

Troponin C, fast skeletal muscle (sTnC) is a protein that in humans is encoded by the TNNC2 gene. It is the troponin C paralog expressed in fast-twitching fibers of skeletal muscle.^[5]^[6]

AliasesTNNC2, troponin C2, fast skeletal type, CFAP85, FAP85

External IDsOMIM: 191039; MGI: 98780; HomoloGene: 55727; GeneCards: TNNC2; OMA:TNNC2 - orthologs

Chr.Chromosome 20 (human)^[1]

End45,833,745 bp^[1]

Quick facts TNNC2, Identifiers ...

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Troponin (Tn), is a key protein complex in the regulation of striated muscle contraction, composed of three subunits. The TnI subunit inhibits actomyosin ATPase, the TnT subunit binds tropomyosin and TnC, while the TnC subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin thin filaments. The protein encoded by the TNNC2 gene is the TnC subunit.^[6]

There are already multiple troponin activators that bind to fast skeletal troponin C (TNNC2), of which tirasemtiv^[7] has been tested in multiple clinical trials.^[8]^[9]^[10]

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Troponin C, skeletal muscle

References

Further reading

Related Articles

Related Articles

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"A double-blinded, randomized, placebo-controlled trial to evaluate efficacy, safety, and tolerability of single doses of tirasemtiv in patients with acetylcholine receptor-binding antibody-positive myasthenia gravis"

"Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"