Tsuru River originates in conifer wood of the Kosuge village where is located near Tsuru Pass but soon crosses the border with the Uenohara municipality area. It follows generally a southeastern and southern course to exit into the Sagami River at the Uenohara town.
Except for the area around the river mouth, or one of the river terraces of the Sagami, the Tsuru runs narrow valley between mountains. Nagasaku (長作), Saihara (西原), Yuzurihara (棡原) and another small villages scatter along it. An asphalt paved road, Yamanashi Prefectural Highway 33rd: Uenohara - Tabayama Line, links them to Uenohara town.
Biodiversity is well preserved due to mountain wood and the lack of dam development. Many species of upper stream fish in Japan live; White-spotted Char (Salvelinus leucomaenis), Seema (Oncorhynchus masou), Japanese Fluvial Sculpin (Cottus pollux), Ayu (Plecoglossus altivelis), Amur Minnow (Rhynchocypris lagowskii), Pale Chub (Zacco platypus) and others. Also Forest Green Tree Frog (Rhacophorus arboreus) and Japanese clawed salamander (Onychodactylus japonicus) inhabit this river.
Good water quality allow culture of wasabi.