Tubular carcinoma

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Histopathology of tubular carcinoma, low magnification, H&E stain. It shows the typical features of invasive breast cancer with infiltrative growth pattern, here including invasion into adipose tissue and with an associated fibrous or desmoplastic stromal response. It has the criterion of more than 90% of the tumor composed of small, ovoid or angulated tubules with open lumina. Ductal carcinoma in situ is seen at left as lumina with micropapillary formations (under the larger bland cyst), and was presumably the precursor lesion for the ductal carcinoma.[1]
Histopathology of tubular carcinoma, high magnification, H&E stain. It shows the typical features of tubules lined by a single layer of cuboidal to columnar epithelial cells with small to intermediate sized nuclei low grade nuclei and sparse mitoses (grade 1).[1]

Tubular carcinoma is a subtype of invasive ductal carcinoma of the breast.[2][3] More rarely, tubular carcinomas may arise in the pancreas[4] or kidney.[5] Most tubular carcinomas begin in the milk duct of the breast and spread to healthy tissue around it.[6][7]

Although tubular carcinoma has been considered a special-type tumor,[a] recent trend has been to classify it as a low-grade, invasive NOS carcinoma because there is a continuous spectrum from pure tubular carcinomas to mixed NOS[b] carcinomas with tubular features, depending on the percentage of the lesion that displays tubular features.[10]: 647 

Histology

Tubular carcinomas are generally around 1 cm. or smaller, and are made up of tubules. They are usually low-grade.[2] Elastosis has been noted as common but is not present in all cases.[11]

Prevalence

Prevalence has previously been controversial, with contradictory reports from studies reporting either very low prevalence, or a high prevalence.[10] With the increasing availability of screening mammography, however, tubular carcinomas are being diagnosed earlier, and more recent studies suggest tubular carcinomas represent between 8% and 27% of all breast cancers.[2]

Prognosis

Tubular carcinoma is one of the histologic types of breast cancer with a more favorable outcome.[12]

See also

Notes and references

Further reading

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