Tulobuterol
Chemical compound
From Wikipedia, the free encyclopedia
Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (ホクナリンテープ).[1]
Routes of
administrationInhaled, oral, transdermal patch
administrationInhaled, oral, transdermal patch
Legal status
- AU: S4 (Prescription only)
- In general: ℞ (Prescription only)
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Inhaled, oral, transdermal patch |
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| ECHA InfoCard | 100.168.691 |
| Chemical and physical data | |
| Formula | C12H18ClNO |
| Molar mass | 227.73 g·mol−1 |
| 3D model (JSmol) | |
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Currently, it is only legal in 7 countries: Japan, Germany, China, South Korea, Bangladesh, Pakistan, and Venezuela. It is available in India also.
Synthesis
The oxidation of 2'-chloroacetophenone (1) with selenium dioxide gives o-chlorophenylglyoxal (2). Condensation with tert-butylamine gives the imine (3). Reduction with sodium borohydride completes the synthesis of tulobuterol.[2]