Duff was born in Cleveland, Ohio and then moved to Kennebunk, Maine.[3] He received his early education from the Kennebunk High School.[4] He attended Ohio University, where he graduated in 1993 with a degree in journalism.[3]
Duff began his career at Morgan Stanley in 1994, where he started off as a sales assistant in the Private Wealth group.[5][6]
In 1999, he joined the Galleon Group where he worked as a health care trader for two years.[7]
In 2001, he co-founded a billion-dollar hedge fund called Argus Partners.[7]
From 2007 to 2009, he worked for J.L. Berkowitz which he left in 2009 to pursue a writing career.[7]
In 2013, he published a memoir, The Buy Side.[8][9] The memoir became a bestseller and was included in The New York Times bestseller list.[10] The memoir has been reviewed by multiple publications, including Publishers Weekly and Kirkus Reviews.[11][12][13]
In 2014, Duff was featured on PBS's Frontline: To Catch a Trader.[14]
He is a regular commentator on CNBC's prime time show The Filthy Rich Guide, and was a consultant for Showtime's series Billions.[5][15]