Tweety family member 2

TTYH2
Identifiers
Aliases	TTYH2, C17orf29, Tweety family member 2
External IDs	OMIM: 608855; MGI: 2157091; HomoloGene: 41882; GeneCards: TTYH2; OMA:TTYH2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,262,020 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	114,611,803 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; external globus pallidus; ; corpus callosum; ; subthalamic nucleus; ; pars reticulata; ; medulla oblongata; ; ventral tegmental area; ; pars compacta; ; pons; ; superior vestibular nucleus;
	Top expressed in
	lumbar subsegment of spinal cord; ; left lobe of liver; ; internal carotid artery; ; external carotid artery; ; blastocyst; ; intestinal villus; ; motor neuron; ; duodenum; ; jejunum; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; chloride channel activity; intracellular calcium activated chloride channel activity; volume-sensitive chloride channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; chloride channel complex;
Biological process	chloride transport; chloride transmembrane transport; ion transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	94015
	117160
	ENSG00000141540
	ENSMUSG00000034714
	Q9BSA4
	Q3TH73
	NM_032646; NM_052869; NM_001330453
	NM_053273
	NP_001317382; NP_116035; NP_443101
	NP_444503
	Wikidata
View/Edit Human	View/Edit Mouse

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.^[5] Members of this family function as chloride channels. The encoded protein functions as a calcium²⁺-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.