Type IV filament

Family of cell projections including T2SS and T4P From Wikipedia, the free encyclopedia

The type IV filament (TFF or T4F) is a superfamily of fibrous protein structures assembled in Prokaryotes by machineries that include a set of four evolutionarily related proteins[1]: the eponymous type IV pilin, a prepilin peptidase, an AAA+ ATPase, and an integral cytoplasmic membrane platform.[2]

The TFF superfamily seems to have originated in the last universal common ancestor, from where it diversified into archaella, different type IV pili subtypes, and type II secretion systems.[2]

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