UACA

UACA
Identifiers
Aliases	UACA, NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats
External IDs	OMIM: 612516; MGI: 1919815; GeneCards: UACA
Gene location (Human)
Chr.	Chromosome 15 (human)
End	70,763,558 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	60,787,652 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; pancreatic ductal cell; ; sural nerve; ; cardia; ; renal medulla; ; ventral tegmental area; ; pylorus; ; nipple; ; trigeminal ganglion; ; subthalamic nucleus;
	Top expressed in
	otolith organ; ; ankle; ; utricle; ; muscle of thigh; ; tibialis anterior muscle; ; lumbar spinal ganglion; ; esophagus; ; medial head of gastrocnemius muscle; ; skeletal muscle tissue; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	extracellular region; extracellular exosome; cytoskeleton; nucleus; cytoplasm; cytosol;
Biological process	apoptotic signaling pathway; regulation of NIK/NF-kappaB signaling; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55075
	72565
	ENSG00000137831
	ENSMUSG00000034485
	Q9BZF9
	Q8CGB3
	NM_001008224; NM_018003
	NM_028283; NM_001357407; NM_001357408
	NP_001008225; NP_060473
	NP_082559; NP_001344336; NP_001344337
	Wikidata
View/Edit Human	View/Edit Mouse

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.^[5]^[6]^[7] Diseases associated with UACA include Graves' Disease.^[8] Among its related pathways are signaling by Rho GTPases and Intrinsic Pathway for Apoptosis. An important paralog of this gene is ANKRD24.^[9]