UBCS039

UBCS039
Clinical data
Drug class	Sirtuin-6 (SIRT6) activator
Identifiers
	IUPAC name 4-pyridin-3-yl-4,5-dihydropyrrolo[1,2-a]quinoxaline;
CAS Number	358721-70-7;
PubChem CID	2803797;
ChemSpider	2082397;
ChEMBL	ChEMBL4636092;
Chemical and physical data
Formula	C16H13N3
Molar mass	247.301 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C2C(=C1)NC(C3=CC=CN32)C4=CN=CC=C4;
	InChI InChI=1S/C16H13N3/c1-2-7-14-13(6-1)18-16(12-5-3-9-17-11-12)15-8-4-10-19(14)15/h1-11,16,18H; Key:BSOBGTYXYGHUTD-UHFFFAOYSA-N;

UBCS039 is a drug which acts as a sirtuin-6 (SIRT6) activator. It was the first synthetic SIRT6 activator to be developed, and while it has comparatively lower potency compared to some newer agents, it is still widely used in research. It has antiinflammatory effects and is protective against kidney toxicity, as well as showing beneficial actions against lung and liver damage, cadmium toxicity, and arterial thrombosis.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]