UBCS385

UBCS385 is a drug which acts as a sirtuin-4 (SIRT4) inhibitor. It also inhibits SIRT2 with around the same affinity, but has reasonable selectivity over SIRT1, SIRT3, SIRT5 and SIRT6. As one of the first ligands developed that inhibits SIRT4 with high potency, UBCS385 is useful for basic research into the structure and function of the sirtuin-4 enzyme complex.^[1][2]

Drug classSirtuin-4 (SIRT4) inhibitor

FormulaC₂₄H₁₆ClN₅O₅S₃

Molar mass586.05 g·mol⁻¹

3D model (JSmol)

• Interactive image

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UBCS385

Clinical data
Drug class	Sirtuin-4 (SIRT4) inhibitor
Identifiers
IUPAC name N-[5-(4-nitrophenyl-1-sulfonyl)-1,3-thiazol-2-yl]-2-[(5-chloro-1H-1,3-benzimidazol-2-yl)sulfanyl]-2-phenylacetamide
Chemical and physical data
Formula	C24H16ClN5O5S3
Molar mass	586.05 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1cc(Cl)cc2c1NC(=N2)SC(c1ccccc1)C(=O)NC1=NC=C(S1)S(=O)(=O)c1ccc([N+](=O)[O+])cc1
InChI InChI=InChI=1S/C24H18ClN5O5S3/c25-15-6-11-18-19(12-15)28-24(27-18)37-21(14-4-2-1-3-5-14)22(31)29-23-26-13-20(36-23)38(34,35)17-9-7-16(8-10-17)30(32)33/h1-13,21H,32H2,(H,27,28)(H,26,29,31)/q+2 Key:BZKNNWDMWJKHJB-UHFFFAOYSA-N

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