UBE1L

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.^[5][6]

AliasesUBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7

External IDsOMIM: 191325; MGI: 1349462; HomoloGene: 2502; GeneCards: UBA7; OMA:UBA7 - orthologs

Chr.Chromosome 3 (human)^[1]

End49,813,953 bp^[1]

Quick facts UBA7, Identifiers ...

UBA7
Identifiers
Aliases	UBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
External IDs	OMIM: 191325; MGI: 1349462; HomoloGene: 2502; GeneCards: UBA7; OMA:UBA7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,805,209 bp[1] End 49,813,953 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 59.07 cM Start 107,852,704 bp[2] End 107,861,259 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen right uterine tube lymph node appendix duodenum gallbladder right ovary left ovary right lobe of thyroid gland Top expressed in granulocyte spleen blood duodenum thymus mesenteric lymph nodes submandibular gland jejunum intestinal villus ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding ISG15 activating enzyme activity nucleotide binding ubiquitin-like modifier activating enzyme activity ligase activity protein binding ubiquitin-protein transferase activity ubiquitin activating enzyme activity Cellular component nucleoplasm cytosol cytoplasm nucleus Biological process negative regulation of type I interferon production ISG15-protein conjugation protein ubiquitination modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7318 74153 Ensembl ENSG00000182179 ENSMUSG00000032596 UniProt P41226 n/a RefSeq (mRNA) NM_003335 NM_023738 RefSeq (protein) NP_003326 n/a Location (UCSC) Chr 3: 49.81 – 49.81 Mb Chr 9: 107.85 – 107.86 Mb PubMed search [3] [4]
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.^[6]