UBE4A

UBE4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGM
Identifiers
Aliases	UBE4A, E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS
External IDs	OMIM: 603753; MGI: 2154580; HomoloGene: 3517; GeneCards: UBE4A; OMA:UBE4A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,399,211 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,876,898 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; visceral pleura; ; parietal pleura; ; pons; ; skin of thigh; ; trigeminal ganglion; ; superior vestibular nucleus; ; inferior ganglion of vagus nerve;
	Top expressed in
	muscle of thigh; ; neural layer of retina; ; genital tubercle; ; spermatocyte; ; ganglion of vagus nerve; ; granulocyte; ; zygote; ; tail of embryo; ; yolk sac; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; transferase activity; ubiquitin-ubiquitin ligase activity;
Cellular component	ubiquitin ligase complex; nucleus; cytoplasm;
Biological process	protein ubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-dependent ERAD pathway; protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9354
	140630
	ENSG00000110344
	ENSMUSG00000059890
	Q14139
	E9Q735
	NM_004788; NM_001204077
	NM_145400; NM_001346698; NM_001361075; NM_001361076
	NP_001191006; NP_004779
	NP_001333627; NP_663375; NP_001348004; NP_001348005
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.^[5]^[6]

PDBOrtholog search: PDBe RCSB

AliasesUBE4A, E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS

External IDsOMIM: 603753; MGI: 2154580; HomoloGene: 3517; GeneCards: UBE4A; OMA:UBE4A - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts Available structures, PDB ...

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

UBE4A

References

Further reading

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