UC-514321

UC-514321
Identifiers
	IUPAC name 6-[(3,5-di-tert-butyl-4-hydroxyphenyl)-morpholin-4-ylmethyl]-1,3-benzodioxol-5-ol;
CAS Number	299420-83-0;
PubChem CID	339892;
ChemSpider	301318;
Chemical and physical data
Formula	C26H35NO5
Molar mass	441.568 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(C2=CC3=C(C=C2O)OCO3)N4CCOCC4;
	InChI InChI=1S/C26H35NO5/c1-25(2,3)18-11-16(12-19(24(18)29)26(4,5)6)23(27-7-9-30-10-8-27)17-13-21-22(14-20(17)28)32-15-31-21/h11-14,23,28-29H,7-10,15H2,1-6H3; Key:XNARHFDDQALZPZ-UHFFFAOYSA-N;

FormulaC₂₆H₃₅NO₅

UC-514321 is an experimental drug which acts as an inhibitor of the proteins STAT3 and STAT5. This blocks the transcription of the enzyme Tet methylcytosine dioxygenase 1 (TET1), which plays an important role in the development of some kinds of cancer, primarily acute myeloid leukemia, but also some gliomas and uterine and testicular cancers. In tests on mice it was effective at delaying the progression of leukemia.^[1]

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Identifiers

IUPAC name 6-[(3,5-di-tert-butyl-4-hydroxyphenyl)-morpholin-4-ylmethyl]-1,3-benzodioxol-5-ol
CAS Number	299420-83-0
PubChem CID	339892
ChemSpider	301318
Chemical and physical data
Formula	C₂₆H₃₅NO₅
Molar mass	441.568 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(C2=CC3=C(C=C2O)OCO3)N4CCOCC4
InChI InChI=1S/C26H35NO5/c1-25(2,3)18-11-16(12-19(24(18)29)26(4,5)6)23(27-7-9-30-10-8-27)17-13-21-22(14-20(17)28)32-15-31-21/h11-14,23,28-29H,7-10,15H2,1-6H3 Key:XNARHFDDQALZPZ-UHFFFAOYSA-N

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