UDP-N-acetylglucosamine diphosphorylase
Class of enzymes
From Wikipedia, the free encyclopedia
UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the reversible chemical reaction
| UDP-N-acetylglucosamine diphosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 N-acetyl glucosamine 1-phosphate uridyltransferase homotrimer, Mycobacterium tuberculosis | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.7.23 | ||||||||
| CAS no. | 9023-06-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme first characterised from sheep brain combines uridine triphosphate and N-acetyl-α-D-glucosamine 1-phosphate (1) to give uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), with pyrophosphate (PPi) as a byproduct.[1][2] Initially, the enzyme was found to be catalysing the breakdown of UDP-GlcNAc but subsequent studies of the enzyme from Escherichia coli showed it to be involved in the biosynthesis of that compound.[3][4][5][6]
The crystal structure of two human isoforms of the enzyme have been determined.[7]
Nomenclature
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase.[8]
