UGT1A10

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.^[5][6][7]

AliasesUGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP glucuronosyltransferase family 1 member A10, UGT1-01, UGT-1A, hUG-BR1, UGT1, UGT1A, UGT1.1, GNT1, UGT1A1

External IDsOMIM: 606435; MGI: 3576092; HomoloGene: 133281; GeneCards: UGT1A10; OMA:UGT1A10 - orthologs

Chr.Chromosome 2 (human)^[1]

End233,773,300 bp^[1]

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UGT1A10
Identifiers
Aliases	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP glucuronosyltransferase family 1 member A10, UGT1-01, UGT-1A, hUG-BR1, UGT1, UGT1A, UGT1.1, GNT1, UGT1A1
External IDs	OMIM: 606435; MGI: 3576092; HomoloGene: 133281; GeneCards: UGT1A10; OMA:UGT1A10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,636,448 bp[1] End 233,773,300 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,998,522 bp[2] End 88,146,719 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum rectum gallbladder olfactory zone of nasal mucosa appendix gastric mucosa epithelium of colon body of stomach islet of Langerhans Top expressed in hepatobiliary system liver duodenum embryo colon renal cortex proximal tubule stomach human kidney ileum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity protein heterodimerization activity enzyme binding protein kinase C binding glucuronosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum endoplasmic reticulum membrane Biological process negative regulation of cellular glucuronidation xenobiotic glucuronidation flavone metabolic process metabolism negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process cellular glucuronidation flavonoid glucuronidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54575 394434 Ensembl ENSG00000242515 ENSMUSG00000090175 UniProt Q9HAW8 Q62452 RefSeq (mRNA) NM_019075 NM_201644 RefSeq (protein) NP_061948 NP_964006 Location (UCSC) Chr 2: 233.64 – 233.77 Mb Chr 1: 88 – 88.15 Mb PubMed search [3] [4]
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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.^[7]