UGT2B15

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.^[5][6]

AliasesUGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP glucuronosyltransferase family 2 member B15

External IDsOMIM: 600069; MGI: 1919023; HomoloGene: 133957; GeneCards: UGT2B15; OMA:UGT2B15 - orthologs

Chr.Chromosome 4 (human)^[1]

End68,670,652 bp^[1]

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UGT2B15
Identifiers
Aliases	UGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP glucuronosyltransferase family 2 member B15
External IDs	OMIM: 600069; MGI: 1919023; HomoloGene: 133957; GeneCards: UGT2B15; OMA:UGT2B15 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 68,646,597 bp[1] End 68,670,652 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 87,064,497 bp[2] End 87,074,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder liver right lobe of liver gonad islet of Langerhans duodenum mucosa of transverse colon body of pancreas body of stomach rectum Top expressed in left lobe of liver embryo lumbar subsegment of spinal cord right ventricle tibiofemoral joint sexually immature organism medial head of gastrocnemius muscle lumbar spinal ganglion stria vascularis carotid body More reference expression data BioGPS n/a
Gene ontology Molecular function hexosyltransferase activity glucuronosyltransferase activity glycosyltransferase activity transferase activity retinoic acid binding UDP-glycosyltransferase activity Cellular component endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle integral component of membrane organelle membrane endoplasmic reticulum Biological process steroid metabolic process cellular glucuronidation metabolism xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7366 71773 Ensembl ENSG00000277132 ENSG00000196620 ENSMUSG00000035836 UniProt P54855 Q8R084 RefSeq (mRNA) NM_001076 NM_152811 RefSeq (protein) NP_001067 NP_690024 Location (UCSC) Chr 4: 68.65 – 68.67 Mb Chr 5: 87.06 – 87.07 Mb PubMed search [3] [4]
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The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM]^[6]