ULBP2

ULBP2
Identifiers
Aliases	ULBP2, N2DL2, RAET1H, ALCAN-alpha, NKG2DL2, UL16 binding protein 2, RAET1L
External IDs	OMIM: 605698; HomoloGene: 130743; GeneCards: ULBP2; OMA:ULBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,949,235 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; mucosa of pharynx; ; oral cavity; ; cartilage tissue; ; stromal cell of endometrium; ; sperm; ; amniotic fluid; ; cervix epithelium; ; right lung; ; middle temporal gyrus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding; protein binding;
Cellular component	cell surface; anchored component of plasma membrane; anchored component of membrane; membrane; extracellular region; extracellular space; plasma membrane; endoplasmic reticulum; external side of plasma membrane;
Biological process	natural killer cell activation; natural killer cell mediated cytotoxicity; immune system process; viral process; T cell mediated cytotoxicity; immune response; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	80328
	n/a
	ENSG00000131015
	n/a
	Q9BZM5
	n/a
	NM_025217
	n/a
	NP_079493
	n/a
	Wikidata
View/Edit Human

UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6.^[3]^[4] ULBP2 is related to MHC class I molecules, but its gene maps outside the MHC locus.^[3]^[4] The domain structure of ULBP2 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.^[3]^[4]