ULK2
From Wikipedia, the free encyclopedia
Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.[1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.
Structure and function
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.[3]
