USP22

USP22
Identifiers
Aliases	USP22, USP3L, ubiquitin specific peptidase 22
External IDs	OMIM: 612116; MGI: 2144157; HomoloGene: 52664; GeneCards: USP22; OMA:USP22 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	21,043,760 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	61,065,881 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; ganglionic eminence; ; middle frontal gyrus; ; frontal pole; ; stromal cell of endometrium; ; Brodmann area 10; ; ventricular zone; ; right hemisphere of cerebellum; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus; ; medial geniculate nucleus; ; anterior amygdaloid area; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; transcription coactivator activity; zinc ion binding; H4 histone acetyltransferase activity; metal ion binding; peptidase activity; protein binding; nuclear receptor coactivator activity; thiol-dependent deubiquitinase; enzyme binding; hydrolase activity;
Cellular component	SAGA-type complex; SAGA complex; nucleus; nucleoplasm; nuclear speck;
Biological process	regulation of transcription, DNA-templated; ubiquitin-dependent protein catabolic process; positive regulation of mitotic cell cycle; transcription, DNA-templated; proteolysis; positive regulation of transcription, DNA-templated; histone deubiquitination; cell cycle; histone ubiquitination; histone H4 acetylation; protein deubiquitination; embryo development ending in birth or egg hatching; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	23326
	216825
	ENSG00000124422
	ENSMUSG00000042506
	Q9UPT9
	Q5DU02
	NM_015276
	NM_001004143
	NP_056091
	NP_001004143
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17.^[5] USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.^[6]