UTY (gene)

PDBHuman UniProt search: PDBe RCSB

AliasesUTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C

External IDsOMIM: 400009; GeneCards: UTY; OMA:UTY - orthologs

Chr.Y chromosome (human)^[1]

UTY
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L
Identifiers
Aliases	UTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDs	OMIM: 400009; GeneCards: UTY; OMA:UTY - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.221 Start 13,234,577 bp[1] End 13,480,673 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad corpus callosum testicle tendon of biceps brachii rectum right lung prostate cartilage tissue corpus epididymis middle frontal gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity dioxygenase activity histone H3-tri/di-methyl-lysine-27 demethylase activity metal ion binding histone demethylase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding chromatin DNA binding sequence-specific DNA binding Cellular component nucleus nucleoplasm MLL3/4 complex Biological process regulation of gene expression histone H3-K27 demethylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7404 n/a Ensembl ENSG00000183878 n/a UniProt O14607 n/a RefSeq (mRNA) NM_001258249 NM_001258250 NM_001258251 NM_001258252 NM_001258253 NM_001258254 NM_001258255 NM_001258256 NM_001258257 NM_001258258 NM_001258259 NM_001258260 NM_001258261 NM_001258262 NM_001258263 NM_001258264 NM_001258265 NM_001258266 NM_001258267 NM_001258268 NM_001258269 NM_001258270 NM_007125 NM_182659 NM_182660 NM_001400170 NM_001400171 NM_001400173 NM_001400175 NM_001400177 NM_001400178 NM_001400181 NM_001400183 NM_001400185 NM_001400187 NM_001400189 NM_001400192 NM_001400195 NM_001400199 n/a RefSeq (protein) NP_001245178 NP_001245179 NP_001245180 NP_001245181 NP_001245182 NP_001245183 NP_001245184 NP_001245185 NP_001245186 NP_001245187 NP_001245188 NP_001245189 NP_001245190 NP_001245191 NP_001245192 NP_001245193 NP_001245194 NP_001245195 NP_001245196 NP_001245197 NP_001245198 NP_001245199 NP_009056 NP_872600 NP_872601 NP_001245196.1 NP_001245192.1 NP_001245178.1 NP_001245194.1 NP_001245186.1 NP_001245191.1 NP_001245187.1 n/a Location (UCSC) Chr Y: 13.23 – 13.48 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Histone demethylase UTY, or Ubiquitously transcribed tetratricopeptide repeat, Y chromosome, is an enzyme that in humans is encoded by the UTY gene.^[3][4][5]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.^[5]

The X-chromosome version of this gene is called UTX.