User talk:Gcmafexpert

February 2012

Your addition to A-N-acetylgalactosaminidase has been removed, as it appears to have added copyrighted material to Wikipedia without permission from the copyright holder. For legal reasons, we cannot accept copyrighted text or images borrowed from other websites or printed material; such additions will be deleted. You may use external websites or publications as a source of information, but not as a source of article content such as sentences or images. Wikipedia takes copyright violations very seriously and persistent violators will be blocked from editing. Yobol (talk) 16:43, 26 February 2012 (UTC)

Please review WP:3RR, WP:MEDRS, WP:V, and WP:RS; if you continue to re-add text without discussing it on talk, you could be blocked. SandyGeorgia (Talk) 17:04, 26 February 2012 (UTC)

SandyGeorgia, i am trying to complete this article the proper way but i cannot do this if the content is constantly altered or deleted. I will proceed to write the item in draft and only post it when it is done. Furthermore , i respond to every message here on Talk or on the userpage in question. WHAT DO YOU MEAN i don't discuss things? See the talk page on Gc-MAF for info --Gcmafexpert (talk) 17:09, 26 February 2012 (UTC)

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GcMAF

Hello Gcmafexpert - Are you still monitoring the Wikipedia GcMAF page? I am also knowledgeable on GcMAF. I would like to talk to you about this subject. And maybe add some updated information. You have to realize that the cancer pharmaceutical industry is deathly afraid of GcMAF and has launched a boycott and disinformation campaign against GcMAF since its discovery. There are paid shills for this industry that monitor the GcMAF page and attack potential updates that they do not like. But they do not have the final say if the post is within Wikipedia guidelines. Let me hear from you on this page if you are still interested in GcMAF and want to improve the GcMAF page. PageMaster (talk) 17:59, 15 August 2025 (UTC)

Yes, i am still here.

How may i help you. Gcmafexpert (talk) 08:47, 16 August 2025 (UTC)

I found this article very usefull in explaining people about GcMAF

https://www.sciencedirect.com/science/article/pii/S2468294222000284?via%3Dihub Gcmafexpert (talk) 08:52, 16 August 2025 (UTC)

And another suggestion: GcMAF activates the VDR receptor.

In inborn errors of bile acid metabolism, there is a reduction/deficiency in the CYP7A1 enzyme.

It appears that activation of VDR, expresses hepatic SHP, which leads to an increase in CYP7A1, which lead to a decrease of cholesterol.

The correlation between excess bile acid and an increased Cholesterol is an indication for a Mitochondrial disease.

PROPOSE: if upregulating VDR leads to resolving eg. "Cholesterol 7a~hydroxylase deficiency (due to a mutation of CYP7A1 gene)" (a mitochondrial illness with a diagnosis delay of 16 years), it can also resolve accute pancreatitis (help to...) and a similar mechanism can perhaps be the tribute to the "key" function GcMAF often has. When adding GcMAF to treatment, patients have a better outcome.

I propose this is twofold; on one side there may be a lot of patients with eg cancer who also have an undiagnosed mitochondrial disease and on the other, it may help to correct Cancer StemCells....???

Last but not least, it can help thousands of MITO patients world wide who currently are doomed. They are reffered to nutritional therapies while Stemmcell therapy with electroferese can put a large % of MITO patients in remission or halt agressive progress of the disease.

(i presume we can talk freely here) Gcmafexpert (talk) 09:03, 16 August 2025 (UTC)

Yes, we can talk freely here. There is much more to GcMAF than scientist realize. I guess you know that GcMAF has successfully completed a FDA registered Phase 1 Clinical Trial with flying colors at the Sheba Hospital (their NIH) in Israel under the name EF-022. In other words, GcMAF could be legally used "Under Right to Try" in the U.S and other countries that have similar laws if some reputable biolab made it. It could be made from powdered Vitamin D Binding Proteins which are available on-line from a reputable blood products supplier. The 2 enzymes needed are also available on-line from a supplier. Also, a Sheba Hospital representative made a presentation at the 2015 AACR Conference in November of 2015 on Part 1 of this 2 Part Phase 1 Trial. I think the fact that a Phase 1 Trial was completed and posted as completed in the National Library of Medicine maintained by the NIH should be a valid reference. Also, a statement or two on the GcMAF page on these trial results as presented to an international cancer conference hosted by the AACR in front of cancer experts from all over the world using the AACR proceedings as a reference would be valid. Information relative to these 2 referenced facts should be posted on the GcMAF Page.

The Sheba representative did not give out copies of her presentation to anyone at the conference. The AACR secretary compiling the write-up for the published proceedings had to ask attendees at the conference to provide copies of their notes for the secretary to edit for the official proceedings (conference minutes). Then these 10 content donors all validated and approved the secretary's writeup as shown at the bottom of the published proceeding for this trial. So, the information on the Phase 1 Trial came from the AACR secretary and the 10 attendees of the presentation. These conference proceedings are published for reference by all the world's cancer experts. So, these results are published by a highly reputable source and peer reviewed and no retraction or changes have been made, and these trial results are now part of GcMAF history.

Here are the links to these references

In May 2017 the Sheba Hospital in Israel successfully completed a cancer-related GcMAF (under the name EF-022) FDA registered Phase 1 Clinical Trial. (Subsequent to this trial a pharmaceutical entity (told it was Genetech) bought out and immediately closed Efranat Ltd to stop further development of GcMAF. There is a conspiracy in the West to boycott GcMAF, but not in Asia where it is expanding. Results from Part 1 of this trial were presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held November 5-9, 2015 in Boston, Massachusetts:

https://mct.aacrjournals.org/content/14/12_Supplement_2/B30

https://clinicaltrials.gov/study/NCT02052492

Do you think these 2 factual EVENTS can be added to the GcMAF page? The completion of the Phase 1 Trial is a historical event and the discussion of GcMAF at the AACR conference is a documented event. If so, would you do the honors as the Gcmafexpert? PageMaster (talk) 19:09, 16 August 2025 (UTC)

It is good to have information on supplemental human GcMAF on these TALK pages for reference by those curious about GcMAF. Since you are the Gcmafexpert, you should have a popular TALK page. I used GOleic until Immuno Biotech Ltd was closed for political reasons. (Power and influence of the EU cancer industry was used to pressure the MHRA into closing Immuno Biotech Ltd to eliminate the business threat from a completely safe, unpatentable, all-natural cancer cure. There are no adverse side or after-effects when using GcMAF.)

Also, the GcMAF protein itself has stand=alone positive effects in the body. I think you are describing one of these effects above. These effects are highly technical as you described above. One attribute of GcMAF proteins is the ability to coax cancer stem cells back to normal which is the way that a cancer is completely cured via GcMAF.

When GcMAF reaches the cancer microenvironment and swallowed by a TAM there (M0, M1 or M2), an epigenetical change occurs in the affected microphage to switch OFF its ZEB2 gene which is normally ON for all microphages. The ZEB2 gene is the master switch gene which turns pro-cancer macrophages or waffling M1s into solidly anti-cancer TAMs. The problem is the cancer microenvironment is usually highly deficient in GcMAF because of cancer's Nagalase countermeasure. Nagalase destroys VDBP's to the point that B and T Cells cannot make sufficient GcMAF to make a difference. So, there is a drastic GcMAF deficiency in the cancer microenvironment. The only way to correct for this is via biolab produced identical supplemental human GcMAF. Nagalase has no effect on pre-formed, supplemental GcMAF. A biolab can easily and cheaply make GcMAF from powdered VDBP from an on-line blood products lab and purchased enzymes. But the dosage of supplemental human GcMAF is critical to convert as many TAMs as needed to switch the M1 & (M3)/M2 ratio against the cancer.

Current Biology currents lumps GcMAF polarized macrophages into the M1 phenotype. M1s have the ZEB2 gene ON and are influenced by other genes which react to external influences to determine their character and behavior in the cancer microenvironment. The ZEB2 gene when turned OFF by GcMAF shunts all the other phenotype affecting genes and turns the macrophage into a dedicated cancer killer. The ZEB2 gene is the master programming switch for macrophages. GcMAF polarized macrophages should be in a separate phenotype, like M3.

Current cancer therapies ignore TAMs to the detriment of all solid cancer patients. This is a gaping hole in current cancer therapies. This ignorance gives cancer an advantage since TAM's generally support cancer's growth and spread. If supplemental human GcMAF were added to this therapy, then current therapies would be closing this vulnerability and have much better results. But again, GcMAF dosage is critical and dosages much more than 100 ng dosages as used in the beginning are needed to show amazing results. It was the 1,000 ng dosages that quickly stopped the terminal cancers in the Efranat Phase 1 Clinical Trial.

The current GcMAF page has a negative slant on GcMAF and this needs to be challenged. It would be great if the 2 references I gave you could be incorporated into the GcMAF page to offset this negativity even if these could be listed as just actual real EVENTS without any further explanation. It is an undisputed fact that a GcMAF study under the name EF-022 is listed in the National Library of Medicine. It is a fact that a favorable GcMAF presentation was made at the 2015 AACR conference. It's an honor to be asked to make a presentation at a AACR conference. These EVENTS do not need a discussion of their meaning. Just posting that these events happened is enough. When the link to the reference is posted at the bottom, anyone interested in GcMAF can click on the link and read the information.

Hope you are willing to do this since it has been so long since I tried to post that I have forgotten how. Another editor actually made the earlier post for me that Efranat Ltd was conducting this FDA registered Phase 1 Clinical Trial. It was a battle to get this posted as you can see on the GcMAF TALK page. But I won and the main Editor objecting to this post finally relented and made the post for me. But since Efranat Ltd was closed by subterfuge, someone deleted this earlier post. (Someone who wanted to keep the GcMAF page negative.) PageMaster (talk) 22:40, 17 August 2025 (UTC)

Dear pagemaster. I figured out where you are located and thought to know with whom i was dealing. At this point i believe i know where you are but question your identity. It is not safe enough to speak openly here. When i was revisiting the GcMAF info, i read someone has been sent to jail in 2 countries for his work. I know of clinics all over the world being closed back then and i know the personal true story about the US doctor who died by gunshot.

I also know that the FDA was forced to conduct their own safety and effectivity tests, as they could not stop the product from entering the country....

I also know about options to produce in smaller labs, subject to local law, usually only to be distributed to doctors who sign for the acknowledgement of administering a 'non proven' treatment, along with the patient. It is then allowed to 'manufacture, distribute & sell', although the laws may differ for each step in that sequence.

I would love to pick things up.... but unfortunately gcmaf alone is not enough for me and i am being denied healthcare in my country. On the brink of death i am still trying to try and get things reorganized, but i am not the one for politics and i litterally do not have the time to share knowledge, check facts, post, counteract retractions etc etc. The thought alone wears me out.

unless a clinic or doctor somewhere can get me back on my feet (mind you, i have put myself in full remission about 6 times total but lack funds and ability to persue this further on my own) i will stick to documenting my case to add to the autopsie report so someone can try and make a statement at some point. It will leave a mark worldwide. And the reorganization bit ;-) Gcmafexpert (talk) 11:21, 20 August 2025 (UTC)

Gcmafexpert - Good to hear from you. Sorry to hear about your situation and hope you win out. I am familiar with all the past history of GcMAF. All the trouble was instigated by the powers-that-be in the West's cancer industry pressuring the MHRA (UK), ANSM (France) and FDA (U.S.) to intervene and block the use of supplemental human GcMAF as an unapproved drug. None of these countries conducted any studies to know whether GcMAF could cure cancer or not. GcMAF was classed as a natural supplement in Germany and the Swiss did not prosecute the CEO of Immuno Biotech. The FDA was about to bring charges against Dr. Jeff Bradstreet for using GcMAF to treat autism when he ended it. So, the problem was with these 3 regulatory agencies that was being misled and manipulated by a powerful, influential, evil pharmaceutical cabal. This cabal exists today with the goal of suppressing GcMAF and maintaining its boycott. GcMAF is a threat to their empire. But it is used in private clinics in Japan and has recently spread from Japan back into Europe. I am a retired, private citizen in America who used GOleic until the MHRA stopped its production. As a matter of fact, I had an order in for 2 (100 ng) vials when the FDA issued their ban on GcMAF imports. So, I lost the money and vials because of this corruption. All of this was before Efranat Ltd completed their FDA registered Phase 1 Clinical Trial. This changes everything. Before the trial they could say and did say that GcMAF was never officially tested for safety. This trial proves to the world that GcMAF is extremely safe and has an effect on cancer. If a reputable biolab made it, it could be sold under "Right to Try" now in America. This would create the demand needed to crush the opposition.

I found out from another GOleic user here in the states about bovine GcMAF. It is made from cow colostrum and is not as strong as human GcMAF. You have to use many more ngs of bovine GcMAF to approximate the strength

and efficacy of injectable supplement human GcMAF. Bovine GcMAF is a natural supplement and not subject to the rules of a biologic. It is applied topically and/or under the tongue. I order it from GcMAFPlus in Australia. They do have distributors in a number of countries for local access. They do let deserving individuals trial their products free of charge. You can contact them on their website, if interested.

Since I am not a doctor or researcher and retired from AT&T management, I cannot be intimated by these lowlifes who are content to block a cancer cure for greed. PageMaster (talk) 23:52, 20 August 2025 (UTC)