VUBI1

VUBI1 is a drug that acts as an activator of the guanine nucleotide exchange factor protein SOS1, increasing the rate at which it catalyzes the exchange of GDP for GTP on its target protein KRAS. While inhibitors of SOS1 have been more widely researched for the treatment of cancer, under some conditions increasing SOS1 activity can also have an anti-cancer effect by destructive overactivation of cellular signaling processes, so SOS1 activators are also of potential clinical interest, as well as being used for the study of the SOS1-KRAS intercellular pathway.^[1][2]

Drug classSOS1 activator

CAS Number

• 2245237-53-8

PubChem CID

• 134814234

FormulaC₂₆H₃₂ClFN₆

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VUBI1

Clinical data
Drug class	SOS1 activator
Identifiers
IUPAC name 6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)benzimidazole
CAS Number	2245237-53-8
PubChem CID	134814234
Chemical and physical data
Formula	C26H32ClFN6
Molar mass	483.03 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=CC(=C1F)C)CN2C3=C(C(=CC(=C3)Cl)N4CCN(CC4)C)N=C2N5CC6(C5)CNC6
InChI InChI=1S/C26H32ClFN6/c1-17-8-19(9-18(2)23(17)28)12-34-22-11-20(27)10-21(32-6-4-31(3)5-7-32)24(22)30-25(34)33-15-26(16-33)13-29-14-26/h8-11,29H,4-7,12-16H2,1-3H3 Key:JWZAQUXBYYOGFA-UHFFFAOYSA-N

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